2
1
35
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3211 |
Midostaurin
米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱 |
Others; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Others |
Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂,有抗肿瘤活性,对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。 | |||
T35599 |
Neuropeptide Y (3-36) (human, rat) (trifluoroacetate salt)
|
||
Neuropeptide Y (NPY) (3-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion. NPY (3-36) is an endogenous peptide produced by cleavage of NPY by dipeptidyl peptidase 4 (DPP-4). It binds selectively to the NPY receptor Y2 (Ki = 0.41 nM in CHP 234 cells) over the Y1 receptor, where it does not bind at concentrations up to 1 μM. NPY (3-36) (0.1 nM) increases migration of human umbilical vein endothelial... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T75491 | 3-(2-Hydroxyethyl) thio withaferin A | ||
3-(2-Hydroxyethyl) thio withaferin A 为Withaferin A衍生物,后者为甾体内酯,能够抑制NF-kB活性并靶向波形蛋白(vimentin),展现出抗炎及抗肿瘤效果。此外,Withaferin A亦为内皮蛋白C受体(EPCR)脱落的抑制剂。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03347 |
EPCR Protein, Rat, Recombinant (His)
protein C receptor, endotheli... |
Rat | HEK293 Cells |
EPCR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.2 kDa. | |||
TMPY-03832 |
EPCR Protein, Cynomolgus, Recombinant (hFc)
protein C receptor, endotheli... |
Cynomolgus | HEK293 Cells |
EPCR Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is XP_001100647.1. | |||
TMPY-03594 |
EPCR Protein, Cynomolgus, Recombinant (His)
protein C receptor, endotheli... |
Cynomolgus | HEK293 Cells |
EPCR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.3 kDa. | |||
TMPY-03192 |
EPCR Protein, Human, Recombinant (hFc)
CCCA,protein C ... |
Human | HEK293 Cells |
EPCR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is AAH14451.1. | |||
TMPY-02715 |
EPCR Protein, Human, Recombinant (His)
EPCR,CCD41,CC |
Human | HEK293 Cells |
EPCR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.4 kDa and the accession number is Q9UNN8. | |||
TMPY-02489 |
EPCR Protein, Mouse, Recombinant (hFc)
Ccd41,Ccca,Ep |
Mouse | HEK293 Cells |
EPCR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.3 kDa and the accession number is Q64695. | |||
TMPY-02487 |
EPCR Protein, Mouse, Recombinant (His)
Ccd41,Ccca,AI32... |
Mouse | HEK293 Cells |
EPCR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.7 kDa and the accession number is Q64695. | |||
TMPK-00562 |
CD31/PECAM-1 Protein, Cynomolgus, Recombinant (His)
FLJ58394,PECAM-1,GPIIA',FLJ34100,EndoCAM,P... |
Cynomolgus | HEK293 Cells |
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation of cellular responsiveness. CD31/PECAM-1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 65.30 kDa and the accession number is A0A7N9CHZ3. | |||
TMPK-00978 |
ECSCR Protein, Human, Recombinant (hFc)
ECSM2,ECSCR,ARIA |
Human | HEK293 Cells |
Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC... | |||
TMPK-00988 |
ECSCR Protein, Mouse, Recombinant (hFc)
ECSCR,ARIA,ECSM2 |
Mouse | HEK293 Cells |
Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC... | |||
TMPK-00834 |
CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His)
PECAM-1,FLJ58394,GPIIA',PECA1,EndoC |
Human | HEK293 Cells |
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation of cellular responsiveness. CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 65.6 kDa and the accession number is P16284-1. | |||
TMPK-00833 |
CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, hFc)
FLJ34100,EndoCAM,PECA1,PECAM-1,FL... |
Human | HEK293 Cells |
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation of cellular responsiveness. CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 91.2 kDa and the accession number is P16284-1. | |||
TMPK-00645 |
VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)
KRD1,VEGFR2,FLK1,CD309,Ly73,VEGFR,VEGFR-21,KDR |
Rhesus | HEK293 Cells |
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis. VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with ... | |||
TMPK-00454 |
VEGFR2/KDR Protein, Human, Recombinant (His & Avi)
VEGFR-21,Ly73,KRD1,VEGFR2,CD309,FLK1,VEGFR,KDR |
Human | HEK293 Cells |
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis. VEGFR2/KDR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-H... | |||
TMPH-03368 |
SG3/Secretogranin 3 Protein, Rat, Recombinant (His & Myc)
|
Rat | E. coli |
Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway. SG3/Secretogranin 3 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 58.2 kDa and the accessio... | |||
TMPK-00133 |
GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His)
GITR-D,AITR,GITR,CD357,TNFRSF18 |
Human | HEK293 Cells |
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His) is expressed in HEK293 mamma... | |||
TMPK-01086 |
GITR/TNFRSF18 Protein, Mouse, Recombinant (aa 22-153, His)
TNFRSF18,AITR,GITR-D,CD357,GITR |
Mouse | HEK293 Cells |
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. GITR/TNFRSF18 Protein, Mouse, Recombinant (aa 22-153, His) is expressed in HEK293 mamma... | |||
TMPK-00132 |
GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His & Avi), Biotinylated
GITR-D,CD357,AITR,GITR,TNFRSF18 |
Human | HEK293 Cells |
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His & Avi), Biotinylated is expre... | |||
TMPK-01260 |
GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (aa 20-156, His)
TNFRSF18,GITR-D,AITR,CD357,GITR |
Cynomolgus | HEK293 Cells |
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (aa 20-156, His) is expressed in HEK293 ... | |||
TMPH-00343 |
Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His)
Angiopoietin-1,ANG-1,ANGPT1 |
Canine | HEK293 Cells |
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His) is expressed in HEK293 mammalian cells wi... | |||
TMPH-03239 |
Angiopoietin-1 Protein, Rat, Recombinant (His)
ANG-1,ANGPT1,Angiopoietin-1 |
Rat | HEK293 Cells |
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis ... | |||
TMPH-00479 |
Angiopoietin-1 Protein, Canine, Recombinant (His)
ANG-1,ANGPT1,Angiopoietin-1 |
Canine | Baculovirus Insect Cells |
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Canine, Recombinant (His) is expressed in Baculovirus insect cells with C-6... | |||
TMPH-02922 |
SRPX2 Protein, Mouse, Recombinant (His & Myc)
|
Mouse | Baculovirus Insect Cells |
Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations. SRPX2 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N... | |||
TMPH-02974 |
Von Willebrand Factor/vWF Protein, Mouse, Recombinant (His & Myc)
|
Mouse | E. coli |
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Von Willebrand Factor/vWF Protein, Mouse, Recombinant (His & Myc) is expressed in E.... | |||
TMPH-02923 |
SRPX2 Protein, Mouse, Recombinant (His & Myc & SUMO)
|
Mouse | E. coli |
Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations. SRPX2 Protein, Mouse, Recombinant (His & Myc & SUMO) is expressed in E. coli expression syste... | |||
TMPJ-00110 |
GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His)
Tnfrsf18,GITR-D,CD357,AITR,Tumor necrosis ... |
Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and... | |||
TMPJ-00012 |
CXCL4 Protein, Human, Recombinant (His)
SCYB4,PF4,Iroplact,Platelet Facto... |
Human | HEK293 Cells |
Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokin... | |||
TMPJ-00884 |
CXCL9 Protein, Mouse, Recombinant (His)
Protein m119,C-X-C motif c |
Mouse | HEK293 Cells |
Chemokine (C-X-C motif) ligand 9 (CXCL9, MIG), is a small cytokine belonging to the CXC chemokine family. CXCL9 functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. It together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour e... | |||
TMPJ-00304 |
ALK-1 Protein, Mouse, Recombinant (hFc)
TSR-I,Serine/threonine-protein kinase rece... |
Mouse | HEK293 Cells |
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1... | |||
TMPJ-00857 |
Thrombomodulin Protein, Mouse, Recombinant (His)
Fetomodulin,Thbd,BDCA-3,Thrombomodulin,CD1... |
Mouse | HEK293 Cells |
Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Mouse THBD is corresponding to the extracellular portion of the type I membrane protein. Predominantly synthesized by vascular endothelial cells, THBD inhibits ... | |||
TMPY-02014 |
Coagulation factor VII/F7 Protein, Human, Recombinant (His)
coagulation factor VII (serum prothrombin ... |
Human | HEK293 Cells |
Coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class, and Factor VII (FVII) deficiency is the most frequent among rare congenital bleeding disorders. Factor VII contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. The main role of factor VII is ... | |||
TMPY-01709 |
HIF-1 alpha Protein, Human, Recombinant (His)
bHLHe78,HIF-1 α,hypoxia inducible factor 1... |
Human | E. coli |
HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has... | |||
TMPK-01450 |
HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
KRAS1,MHC,K-RAS4B,KRAS,CFC2,K-RAS... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01456 |
HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein, Human, MHC (His & Avi)
KRAS2,NS,MHC,C-K-RAS,KRAS1,K-RAS2A,K-RAS2B... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01451 |
HLA-C 03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi)
NS3,K-RAS4A,K-Ras 2,NS,KRAS1,RASK2,MHC,KI-RAS,KRAS,... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. |